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Search Results for " folate receptor "

Targets Recommended: Antifolate

13

抑制剂 & 化合物

17

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76766	Mirvetuximab M9346A	Antifolate	Cell Cycle/Checkpoint
	Mirvetuximab (M9346A) 是一种新型叶酸受体α (FRα) 靶向 anti-FOLR1 (folate receptor 1) 的单克隆抗体。Mirvetuximab soravtansine 常与铂类化合物或与其他化合物偶联成为抗体-药物偶联物用来治疗卵巢癌和其他 FRα 阳性的癌症。
T76720	Farletuzumab MORAb-003	Antifolate	Cell Cycle/Checkpoint
	Farletuzumab (MORAb-003) 是一种有效的叶酸受体-α (FRα) 抑制剂。Farletuzumab 是一种对 FRα 具有高亲和力的人源化单克隆抗体。Farletuzumab 抑制过表达 FRα 的细胞的生长。Farletuzumab 可用于研究癌症。
T39757	EC2629 EC2629
	EC2629 is a highly potent folate- receptor-targeted DNA crosslinking agent.
T68232	Epofolate
	Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and s...
T82378	Folate-MS432	PROTACs	PROTAC
	Folate-MS432作为PROTAC，通过叶酸受体依赖途径特异性降解癌细胞中的MEKs。
T38490	ONX 0801 trisodium Idetrexedtrisodium,BGC 945 trisodium,CB300945trisodium
	ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.
T12635L	Plevitrexed BGC9331,ZD 9331	Others	Others
	Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is an orally active and effective thymidylate synthase (TS) inhibitor (Ki: 0.44 nM). Plevitrexed is used for gastric cancer in clinical.
T29434	4-Desacetylvinblastine hydrazide DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide
	Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent.
T69268	BGC-638
	BGC-638, an analogue of BGC-945, is a thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)Â–overexpressing tumors.
T19304	EC-17 disodium salt	Others	Others
	The peak excitation and emission wavelengths of EC-17 are 470/520 nm.EC-17 (disodium salt) is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum.
T13672	EC0489	Others	Others
	EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor.
T77825	Mirvetuximab soravtansine IMGN853
	Mirvetuximab soravtansine (IMGN853)是一种抗体药物偶联物（ADC），包含与人源化单克隆抗体M9346A共价连接的细胞毒素maytansoid DM4。该药物特异性地结合于叶酸受体1 (FOLR1)，显示出抑制细胞生长和增强DNA损伤的抗增殖效果。
T77908	Farletuzumab ecteribulin MORAb-202
	Farletuzumabecteribulin（MORAb-202）是一款人源化抗人叶酸受体α（FRA）抗体Farletuzumab与Mal-PEG2-Val-Cit-PAB-eribulin通过还原的链间二硫键偶联成的抗体-活性分子偶联物（ADC）。该化合物活性分子抗体比率为4.0，对FRA阳性细胞展示出强大的体外细胞毒性，并具备有效的抗肿瘤活性。

化合物

Cat.No: T76766

Synonym: M9346A

Target: Antifolate

Cat.No: T76720

Synonym: MORAb-003

Target: Antifolate

Cat.No: T39757

Synonym: EC2629

Cat.No: T68232

Cat.No: T82378

Target: PROTACs

ONX 0801 trisodium

Cat.No: T38490

Synonym: Idetrexedtrisodium,BGC 945 trisodium,CB300945trisodium

Cat.No: T12635L

Synonym: BGC9331,ZD 9331

Target: Others

4-Desacetylvinblastine hydrazide

Cat.No: T29434

Synonym: DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide

Cat.No: T69268

EC-17 disodium salt

Cat.No: T19304

Target: Others

Cat.No: T13672

Target: Others

Mirvetuximab soravtansine

Cat.No: T77825

Synonym: IMGN853

Farletuzumab ecteribulin

Cat.No: T77908

Synonym: MORAb-202

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00147	FOLR1 Protein, Human, Recombinant (hFc) Folate receptor 1,Folate rece...	Human	HEK293 Cells
	FOLR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-75 kDa and the accession number is P15328.
TMPY-01815	FOLR1 Protein, Human, Recombinant (His) FBP,Folate Binding Protein,folate rece...	Human	HEK293 Cells
	FOLR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is A0A024R5H1.
TMPY-06022	FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His) folate receptor 1 (adult)	Cynomolgus,Rhesus	HEK293 Cells
	FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A2K5UR19&NP_001181576.1.
TMPY-01803	FOLR1 Protein, Mouse, Recombinant (His) folate receptor 1 (adult),Folbp1,FBP1,Folb...	Mouse	HEK293 Cells
	FOLR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is P35846.
TMPY-01280	FOLR2 Protein, Human, Recombinant (His) FBP,β-HFR,FR-P3,BETA-HFR,folate receptor 2...	Human	HEK293 Cells
	Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potoc...
TMPY-00622	FOLR1 Protein, Canine, Recombinant (His) folate receptor 1 (adult)	Canine	HEK293 Cells
	FOLR1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.4 kDa and the accession number is A0A8C0Z2T7.
TMPY-02417	FOLR1 Protein, Canine, Recombinant (hFc) folate receptor 1 (adult)	Canine	HEK293 Cells
	FOLR1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is A0A8C0Z2T7.
TMPJ-00148	FOLR1 Protein, Rhesus macaque, Recombinant (His) FR-alpha,Adult folate-binding protein,Ovarian tumor...	Rhesus	HEK293 Cells
	FOLR1 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-38 kDa and the accession number is F7BP60.
TMPY-06929	FOLR1 Protein, Human, Recombinant (His & Avi), Biotinylated Folate Binding Protein,folate receptor...	Human	HEK293 Cells
	FOLR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 27.83 kDa and the accession number is NP_057937.1.
TMPY-00543	FOLR1 Protein, Rat, Recombinant (His) folate receptor 1 (adult)	Rat	HEK293 Cells
	FOLR1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.7 kDa and the accession number is G3V8M6.
TMPY-04128	FOLR1 Protein, Rat, Recombinant (hFc) folate receptor 1 (adult)	Rat	HEK293 Cells
	FOLR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.9 kDa and the accession number is G3V8M6.
TMPY-06928	FOLR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated FOLR,Folate Binding Protein,folate rec...	Human	HEK293 Cells
	FOLR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 53.11 kDa and the accession number is NP_057937.1.
TMPK-00878	FOLR3 Protein, Human, Recombinant (His) FR-γ,Folate receptor 3,FR-gamma,FR-G	Human	HEK293 Cells
	Folic acid and folate receptors (FOLRs) play an important role in the downregulation of homocysteine (Hcy), a risk factor of Alzheimer's disease, thrombosis, neuropsychiatric illness and fractures.
TMPK-00150	FOLR1 Protein, Human, Recombinant (His & Avi) Folate receptor 1,Folbp1,Folate <...	Human	HEK293 Cells
	Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into t...
TMPK-00585	FOLR4/Juno Protein, Human, Recombinant (His) Folate receptor 4,FR-δ,Folbp3,FR-delta,Izu...	Human	HEK293 Cells
	Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Pro...
TMPK-01171	FOLR4/Juno Protein, Mouse, Recombinant (His) Juno,FOLR4, LOC390243,Folate receptor 4,FR...	Mouse	HEK293 Cells
	Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Pro...
TMPJ-01299	RTBDN Protein, Human, Recombinant (His) Retbindin,RTBDN	Human	HEK293 Cells
	Human Retbindin is a 229 amino acid secreted protein that belongs to the folate receptor family. The gene that encodes retbindin exists as two alternatively spliced isoforms. Retbindin is first expressed in retina. It may play a role in binding retinoids and other carotenoids as it shares homology with;riboflavin binding proteins. RTBDN gene was first identified in a study of human eye tissues.

重组蛋白

FOLR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00147

Species: Human

Expression System: HEK293 Cells

FOLR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01815

Species: Human

Expression System: HEK293 Cells

FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His)

Cat.No: TMPY-06022

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

FOLR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01803

Species: Mouse

Expression System: HEK293 Cells

FOLR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01280

Species: Human

Expression System: HEK293 Cells

FOLR1 Protein, Canine, Recombinant (His)

Cat.No: TMPY-00622

Species: Canine

Expression System: HEK293 Cells

FOLR1 Protein, Canine, Recombinant (hFc)

Cat.No: TMPY-02417

Species: Canine

Expression System: HEK293 Cells

FOLR1 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00148

Species: Rhesus

Expression System: HEK293 Cells

FOLR1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06929

Species: Human

Expression System: HEK293 Cells

FOLR1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-00543

Species: Rat

Expression System: HEK293 Cells

FOLR1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-04128

Species: Rat

Expression System: HEK293 Cells

FOLR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06928

Species: Human

Expression System: HEK293 Cells

FOLR3 Protein, Human, Recombinant (His)

Cat.No: TMPK-00878

Species: Human

Expression System: HEK293 Cells

FOLR1 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00150

Species: Human

Expression System: HEK293 Cells

FOLR4/Juno Protein, Human, Recombinant (His)

Cat.No: TMPK-00585

Species: Human

Expression System: HEK293 Cells

FOLR4/Juno Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01171

Species: Mouse

Expression System: HEK293 Cells

RTBDN Protein, Human, Recombinant (His)

Cat.No: TMPJ-01299

Species: Human

Expression System: HEK293 Cells

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